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KMID : 0378019910340100085
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New Medical Journal
1991 Volume.34 No. 10 p.85 ~ p.90
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A Clinical Trial of Oral Broncho-Vaxom in the Treatment of Acute Recurrent Respiratory Infection in Patients with Chronic Pulmonary Disease
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김관형/Kim, K.H.
권순석/김영균/한기돈/문화식/송정섭/박성학/Kwon, S.S./Kim, Y.K./Hanz, K.D./Moon, H.S./Song, J.S./Park, S.H.
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Abstract
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Broncho-Vaxom, a polyvalent lyophilized bacterial lysate prepared from the pathogenic organisms which are most frequently the cause of acute and chronic respiratory infections, brings about both a non-specific immunostimulation with increased lymphocyte and macrophage activity as well as enhancement of immune-defence mechanism. The objective of the present study was to evaluate the efficacy of Broncho-Vaxom in the treatment of acute recurrent respiratory infection in patients with chronic pulmonary disease.
The first visit of 25 patients with chronic pulmonary disease in acute recurrent respiratory infection, we treated without Broncho-Vaxom for I month. and then the second visit, treated with Broncho-Vaxom for 1 month. We observed the clinical manifestations. WBC & pulmonary function test and compared before with after administration of Broncho-Vaxom,
The result was as follows
1. The more improvement of symptom scores such as cough, dyspnea, expectoration, fever, wheezing in after Broncho-Vaxom group.
2. In after Broncho-Vaxom group, the pulmonary function test tend to be improved than before and especially PEFR was significantly improved (P<0.05).
3. Broncho-Vaxom was well tolerated and side effects with negligible.
These results suggest that Broncho-Vaxom showed the superiority of this immunobiotherapeutic drug over the conventional symptomatic measures.
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